0000098877 00000 n %%EOF To help us improve GOV.UK, wed like to know more about your visit today. Please reach out if you have any feedback on the translation. All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. A full list of ingredients for the qualitative and quantitative composition of the vaccine and a full list of the excipient composition of the vaccine can be found at point 6 in the Summary. AstraZeneca's Oxford vaccine trial to resume, the university says The document, which is labeled an "initial report," describes how the study participant had trouble walking, weakness and pain. JZD| WHO does not recommend discontinuing breastfeeding because of vaccination. It uses a chimpanzee adenovirus to carry spike proteins from the . To get around the problem, scientists used virus from a chimpanzee to ensure people would not have any natural immunity to it. (see section 2. The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. brain, liver, bowel, spleen). What is the evidence for use in older age groups? 3.What if I am taking, have recently taken or might take other medicinesor Moderna bivalent COVID-19 vaccine. trailer Vaccines, by Vaccine In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients - excipients. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. Health information in your inbox, every other week. Can they overcome their checkered past? If you previously had Guillain-Barr syndrome (temporary loss of feeling and movement) or transverse myelitis (inflammation of the spinal cord) after being given COVID-19 Vaccine AstraZeneca. 0000002358 00000 n xref Further to this, SAGE recommends that severe and moderately immunocompromised persons should be offered an additional dose of vaccine. LYpeP4 &=C&CBzLL3y20gah!A '1>ederj4+e@Zg Rc`TaPa`2R6r G2p T The investigation is the latest trouble in Europe for British-Swedish drugmaker AstraZeneca, which has come under pressure to produce more vaccines after it fell tens of millions of doses short. It should be noted that the full two We also use cookies set by other sites to help us deliver content from their services. Epub 2020 Dec 8. 0000102152 00000 n 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca] in pregnant women, or women who became pregnant after receiving the vaccine. 779 0 obj <> endobj vaccination series and are at higher risk of severe COVID-19 disease. %PDF-1.7 % Netherlands. 0000010323 00000 n The Oxford-AstraZeneca vaccine contains no common food allergens such as milk, wheat, egg, peanuts, tree nuts, or shellfish, or their by-products. 0000053643 00000 n Something went wrong while submitting the form. This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally.2 . COVID-19 Vaccine AstraZeneca contains sodium and alcohol (ethanol) This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. The final stage (Phase III) provides the vaccine to thousands of people from the target population to see how safe and effective it is. xcbd```b``A$c0{.fH "uAY@1bFg210MW Last updated by Judith Stewart, BPharm on Feb 15, 2021. Contents of the pack and other information 1. 0000104953 00000 n Over the years, researchers have considered adenoviruses useful delivery systems for vaccines and gene therapies. Systemic reactions were common in the AZD1222 without paracetamol group, with 340 (70%) reporting fatigue and 31 (68%) reporting headache. In the trial, 543 participants received AZD1222 (56 also received a prophylactic dose of the pain killer paracetamol), and 534 received MenACWY, a comparator meningococcal conjugate vaccine. 6 Renaissance Way The AstraZeneca vaccine is based on an adenovirus that circulates in chimpanzees . You can change your cookie settings at any time. There If you are not sure, talk to your doctor, pharmacist or nurse. startxref RZ%L ?Gss0~ls"+?H~9~ ~~g5-?K~=2_H Moderna; you may take J&J vaccine You should not receive the vaccine if: Talk to your medical provider before getting this vaccine to review your medical conditions, including allergies to any of the vaccine ingredients as listed at right, or if you have had severe reactions to other vaccines in the past If you have questions or concerns: 1. Contact your doctor or pharmacist if you have any questions about . any ingredients of COVISHIELD vaccine If you are breastfeeding If you are pregnant or plan to become pregnant WHAT YOU NEED TO KNOW BEFORE YOU GET THIS VACCINE Read this Fact Sheet for information about the COVISHIELD Vaccine. The solution is colourless to slightly brown, clear to slightly opaque. hb```b``9 |Abl,=@00M(P~. 0000006565 00000 n This webpage was updated on 16 March 2022 to reflect the latest guidance and ensure consistency of information and formatting. Andrew Pollard has been leading the Oxford vaccine clinical trials in the UK, Brazil, and South Africa. a severe headache that is not relieved with simple painkillers or is getting worse or feels worse when you lie down or bend over, an unusual headache that may be accompanied by blurred vision, confusion, difficulty with speech, weakness, drowsiness or seizures (fits), rash that looks like small bruises or bleeding under the skin beyond the injection site, or any unexplained bleeding. Dont include personal or financial information like your National Insurance number or credit card details. health workers and immunocompromised persons should be prioritised. are no data yet for Omicron. If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. M Ms CZHto ) The shot gives the body instructions to create the spike protein from COVID-19 in its cells. If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. Safety data sheet. If you are immunocompromised and receive a third dose of COVID-19 Vaccine AstraZeneca, it may still not provide full immunity to COVID-19 and you should continue to maintain physical precautions to help prevent COVID-19. 55 0 obj 0000006617 00000 n COVID-19 Vaccine AstraZeneca is not recommended for children aged below 18 years. 0000019840 00000 n In line with the WHO Prioritization Roadmapand and the WHO Values Framework older adults, Vaccine efficacy tended to be higher when the interval between doses was longer. A lot of people have been infected with adenoviruses like bronchitis during their lifetimes. Vaccine Excipient Summary Excipients Included in U.S. 0000002960 00000 n 0000004065 00000 n 0000006393 00000 n In clinical trials there were very rare reports of events associated with inflammation of the nervous system, which may cause numbness, pins and needles, and/or loss of feeling. Vaxzevria is made up of another virus (of the adenovirus family) that has been modified to contain the gene for making a protein from SARS-CoV-2, the virus that causes COVID-19. Here what's in the Pfizer and AstraZeneca jabs (. To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. Some of the information might be out of date or no longer relevant. The last nine ingredients on the list are called 'excipients.' 0000015573 00000 n 0000006590 00000 n When autocomplete results are available use up and down arrows to review and enter to select. Documents provided by AstraZeneca: Study Protocol [PDF] February 19, 2021 Statistical Analysis Plan [PDF] February 28, 2021 More Information Go to Additional Information: Statistical Analysis Plan (SAP) D8110C00001-CSP-amendment-6_Redacted.pdf CSR Synopsis Publications: CDC. WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. Vaccine AstraZeneca in children and adolescents younger than 18 years of age. 0000004537 00000 n Consumer Information. endstream endobj 75 0 obj <> stream This is not enough to cause any noticeable effects. This type of vaccine development technology has been tested for many other diseases such as influenza (flu) and Middle East respiratory syndrome coronavirus (MERS-CoV). xc```b``g`a```d@ A+s4@s60J:Up95PA? This is due to the fact that this group is less likely to respond adequately to vaccination following a standard primary 57 0 obj <> endobj xref Dont worry we wont send you spam or share your email address with anyone. Generic name: SARS-CoV-2 vaccine 0000002028 00000 n 0000103790 00000 n United Kingdom, MedImmune Pharma B.V., Nijmegen 0000024916 00000 n 346 65 Vaccines are tested and studied in multiple phases (phased testing) to determine if they are safe and work to prevent illness. As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. xVN@}W#E{I HTJB+!`)m;:KQyX99se 803 0 obj <>/Filter/FlateDecode/ID[<2F70D35E7B8A59458B52A8ED8203A71C><24F7C9D4F005C249BEA4CA3B57A534AF>]/Index[779 189]/Info 778 0 R/Length 129/Prev 229930/Root 780 0 R/Size 968/Type/XRef/W[1 3 1]>>stream LqIai8O=,*EM~|>0: NiV|+'#M(FYQc`uic+)Gy1Q(:'4~0:,9Dbdf&. @A20;ia p9I2mL1-bt.S\3=!c`j= y&f" 0M Your immune cells then recognise the spike protein as a threat and begin building an immune response against it. Get urgent medical attention if you get symptoms of a severe allergic reaction. Unit dose strength (s) > 0.7 1011 vp/mL. 0000008310 00000 n Extremely rare cases of blood clots with low levels of blood platelets (thrombosis with thrombocytopenia syndrome) have been observed following vaccination with COVID-19 Vaccine AstraZeneca. That way, when a person is exposed to COVID-19, its immune system will recognize the part of the virus that has those spike proteins and will know how to how to fight it. Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). Information about the Moderna coronavirus vaccine, including a full list of ingredients and side effects, is available: Information on the Moderna COVID-19 vaccine. This publication is licensed under the terms of the Open Government Licence v3.0 except where otherwise stated. %PDF-1.3 % The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international How to store COVID-19 Vaccine AstraZeneca 6. 0000006540 00000 n Any unused vaccine or waste material should be disposed of in accordance with local requirements. WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern.
